Ultrasonic transdermal insulin therapy: a strategy to improve wound healing and support physical performance in diabetic patients

Authors

  • Dalia G El Sayed Department of Physical Therapy for Surgery, Faculty of Physical Therapy, Modern University for Technology and Information, Egypt
  • Mohamed Salah El-Sayed Department of Physical Therapy, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Jordan / Department of Physical Therapy for Pediatrics, Faculty of Physical Therapy, Horus University-Egypt, New Damietta, Egypt
  • Radwa F. Hammam Basic Science Department, Faculty of Physical Therapy, Modern University for Technology and Information, Egypt
  • Shimaa G. El Sayed Department of Physical Therapy for Surgery and Women’s Health, Faculty of Physical Therapy, Sinai University, Egypt
  • Amera S. Aly Department of Physical Therapy for Internal Medicine and Geriatrics, Faculty of Physical Therapy, Alsalam University, Egypt
  • Heba E. Mahmoud Department of Physical therapy for Women’s health, Faculty of Physical Therapy, Sinai University, Egypt
  • Esraa H. Rostom Department of Physical Therapy for Surgery, Faculty of Physical Therapy, Cairo University, Egypt

DOI:

https://doi.org/10.6018/sportk.721751

Keywords:

Transdermal Insulin, Ultrasonic, Wound Healing, Physical Performance, Diabetic Patients

Abstract

The aim of this study was to establish the impact of Transdermal Insulin Therapy in patients with chronic diabetic wound. This double blinded randomized control trial study involved 40 (12 female and 28 male) patients with stage II-III of chronic diabetic foot wound. The patients in the intervention group (I) were subjected, besides Transdermal Insulin Therapy, to Hyperpolarized light therapy and Standard wound cleaning and dressing. Hyperpolarized light therapy and Standard wound cleaning and dressing (standard treatment) were the treatment that were used in the control group (C). All patients were assessed before treatment initiation and then weekly for four consecutive weeks. Post-treatment revealed significant reductions in DIMST score IV (MD=-2.9, effect size=0.79) and DIMST score V (MD=-2.95, effect size=0.81) of the study group in comparison to the control group (p<0.01). Comparing within groups, in the intervention group there was a substantial reduction in score V in comparison with score I, II, III and IV (p<0.001), a substantial reduction in score IV in comparison with score I, II and III (p<0.001), a substantial reduction in score III in comparison with score I and II (p<0.001) and a substantial reduction in score II in comparison with score I (p<0.001). The Transdermal Insulin Therapy by ultrasound has a significant effect on wound healing and supports the physical performance of chronic diabetic foot wound patients, and it should be considered in future treatment plans for diabetic wounds.

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References

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Published

18-06-2026

How to Cite

El Sayed, D. G., El-Sayed, M. S., Hammam, R. F., El Sayed, S. G., Aly, A. S., Mahmoud, H. E., & Rostom, E. H. (2026). Ultrasonic transdermal insulin therapy: a strategy to improve wound healing and support physical performance in diabetic patients. SPORT TK-EuroAmerican Journal of Sport Sciences, 15, 53. https://doi.org/10.6018/sportk.721751

Issue

Vol. 15 (2026)

Section

Articles

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